Subjects include annual reports; births; baptisms; marriages; deaths; buildings and grounds; church finances, governance, history, library, manuals, membership, organizations, and publications; missionary work; pastors; special events; Sunday school; youth programs; Bibles; prayerbooks; music and hymnals; blueprints and maps; and other records of the First Presbyterian Church of Ithaca, Tompkins County, New York.

Map of the city of Rochester, 1889; pamphlet A half century sermon preached in the Presbyterian Church, in Ithaca, February 4, 1866, by Rev. Wm. Wisner (Ithaca: Andrus, McChain & Company, 1866); and Proceedings of the Board of Supervisors of the County of Tompkins, for the year 1864 (Ithaca: Ithaca Journal Power Press, 1864).